Johnson and Johnson Covid-19 vaccine linked to rare syndrome: what's the risk?


Daniel Bardsley
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While Covid-19 vaccines have been credited with saving tens of thousands of lives, there have also been health scares linked to them.

The latest involves the Johnson and Johnson vaccine and a rare neurological condition, Guillain-Barré syndrome (GBS).

This week the US Food and Drug Administration added a warning about GBS to its guidelines for healthcare providers administering the vaccine, which is also known by its Janssen brand name.

Here we look at the condition and consider its apparent association with the vaccine.

What is Guillain-Barré syndrome?

Guillain-Barré syndrome, which the UK’s National Health Service (NHS) says is pronounced “ghee-yan bar-ray”, is caused by the immune system attacking the body’s nerves. Cases frequently follow a bacterial or viral infection, including influenza.

Early symptoms include numbness, weakness, pain and balance problems, which may worsen over several weeks, with the feet, hands and limbs most affected.

In some cases, sufferers find walking, swallowing and even breathing difficult, according to guidance from the NHS, and as symptoms spread, movement as a whole may prove difficult.

Various treatments are available, including blood filtering — called plasma exchange — or the administration of an intravenous substance produced from donated blood.

Hospital stays of weeks or months are typical and there is a risk of death, and some people are left with long-term complications. However, patients usually recover fully.

Children can develop the condition, although it is more common in adults, especially men, and in a typical year there are about 3,000 to 6,000 cases in the US.

Is there a link with vaccination?

According to the US Centres for Disease Control and Prevention there have been about 100 cases of GBS in the country among 12.8 million who have received the Johnson and Johnson vaccine. Of these, 95 were serious, with one fatal.

Symptoms typically developed a two weeks after vaccination and men aged over 50 were most affected.

Last month there were reports of a handful of cases of GBS in the Nottingham area of central England in people who had received the Oxford-AstraZeneca shot. Also some recipients in India and Australia have developed the condition.

The Johnson and Johnson and Oxford-AstraZeneca vaccines are based on similar technology, being viral vector vaccines made from a harmless adenovirus that delivers coronavirus genetic material into cells.

Is vaccination still safe?

While the Johnson and Johnson vaccine appears to increase the chance of developing GBS, the US data indicates that fewer than one recipient in 100,000 falls ill.

As with the Oxford-AstraZeneca vaccine, regulators have not recommended against continued use because of GBS.

“That’s a significant risk and it’s a very serious condition, but at the same time for the average person no doubt vaccination is beneficial,” said Prof David Taylor, professor emeritus of pharmaceutical and public health policy at University College London.

Balanced against the risks of vaccination are the much higher risks from developing Covid-19, which may itself be a risk factor for GBS, although findings are contradictory.

A study from last year looking at cases in England during the first wave of the pandemic found that there were actually fewer reports of the condition in 2020 compared with previous years.

However, Dubai Medical Journal earlier this year reported GBS in a 72-year-old man in Kuwait with Covid-19.

“Neurologists should be aware of GBS as a potentially serious complication associated with Covid-19,” the researchers concluded.

Are there other risks associated with Covid-19 vaccination?

The Johnson and Johnson and Oxford-AstraZeneca vaccines have been linked to a syndrome called immune thrombotic thrombocytopenia, which causes potentially fatal blood clots.

Although these are extremely rare, the risk has caused some countries to impose age restrictions on these vaccines, with younger people often offered an alternative.

Two other vaccines, the Moderna and Pfizer jabs, based on mRNA technology, have been linked to a rare type of heart inflammation called myocarditis, with teenaged boys and young men most at risk.

A report from Harvard Health Publishing earlier this month said there had been about 1,000 cases from millions of vaccine doses.

“The majority of cases have been mild. Experts are still gathering information, but as of this writing, 79 per cent of teenagers and young adults who experienced this had recovered,” wrote Dr Claire McCarthy, a paediatrician at Boston Children’s Hospital and an assistant professor of paediatrics at Harvard Medical School.

She said there was a risk of myocarditis, and other complications, from Covid-19, and the recommendation was for vaccination to continue.

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Ireland (15-1):

Ireland (15-1): Rob Kearney; Keith Earls, Chris Farrell, Bundee Aki, Jacob Stockdale; Jonathan Sexton, Conor Murray; Jack Conan, Sean O'Brien, Peter O'Mahony; James Ryan, Quinn Roux; Tadhg Furlong, Rory Best (capt), Cian Healy

Replacements: Sean Cronin, Dave Kilcoyne, Andrew Porter, Ultan Dillane, Josh van der Flier, John Cooney, Joey Carbery, Jordan Larmour

Coach: Joe Schmidt (NZL)

ENGLAND SQUAD

Eoin Morgan (captain), Moeen Ali, Jonny Bairstow, Sam Billings, Jos Buttler, Tom Curran, Alex Hales, Liam Plunkett, Adil Rashid, Joe Root, Jason Roy, Ben Stokes, David Willey, Chris Woakes, Mark Wood

Jetour T1 specs

Engine: 2-litre turbocharged

Power: 254hp

Torque: 390Nm

Price: From Dh126,000

Available: Now

Wicked
Director: Jon M Chu
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Who's who in Yemen conflict

Houthis: Iran-backed rebels who occupy Sanaa and run unrecognised government

Yemeni government: Exiled government in Aden led by eight-member Presidential Leadership Council

Southern Transitional Council: Faction in Yemeni government that seeks autonomy for the south

Habrish 'rebels': Tribal-backed forces feuding with STC over control of oil in government territory

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If you go

The flights
Emirates and Etihad fly direct to Nairobi, with fares starting from Dh1,695. The resort can be reached from Nairobi via a 35-minute flight from Wilson Airport or Jomo Kenyatta International Airport, or by road, which takes at least three hours.

The rooms
Rooms at Fairmont Mount Kenya range from Dh1,870 per night for a deluxe room to Dh11,000 per night for the William Holden Cottage.

MATCH INFO

Serie A

Juventus v Fiorentina, Saturday, 8pm (UAE)

Match is on BeIN Sports

Pari

Produced by: Clean Slate Films (Anushka Sharma, Karnesh Sharma) & KriArj Entertainment

Director: Prosit Roy

Starring: Anushka Sharma, Parambrata Chattopadhyay, Ritabhari Chakraborty, Rajat Kapoor, Mansi Multani

Three stars

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Dr Afridi's warning signs of digital addiction

Spending an excessive amount of time on the phone.

Neglecting personal, social, or academic responsibilities.

Losing interest in other activities or hobbies that were once enjoyed.

Having withdrawal symptoms like feeling anxious, restless, or upset when the technology is not available.

Experiencing sleep disturbances or changes in sleep patterns.

What are the guidelines?

Under 18 months: Avoid screen time altogether, except for video chatting with family.

Aged 18-24 months: If screens are introduced, it should be high-quality content watched with a caregiver to help the child understand what they are seeing.

Aged 2-5 years: Limit to one-hour per day of high-quality programming, with co-viewing whenever possible.

Aged 6-12 years: Set consistent limits on screen time to ensure it does not interfere with sleep, physical activity, or social interactions.

Teenagers: Encourage a balanced approach – screens should not replace sleep, exercise, or face-to-face socialisation.

Source: American Paediatric Association
Timeline

2012-2015

The company offers payments/bribes to win key contracts in the Middle East

May 2017

The UK SFO officially opens investigation into Petrofac’s use of agents, corruption, and potential bribery to secure contracts

September 2021

Petrofac pleads guilty to seven counts of failing to prevent bribery under the UK Bribery Act

October 2021

Court fines Petrofac £77 million for bribery. Former executive receives a two-year suspended sentence 

December 2024

Petrofac enters into comprehensive restructuring to strengthen the financial position of the group

May 2025

The High Court of England and Wales approves the company’s restructuring plan

July 2025

The Court of Appeal issues a judgment challenging parts of the restructuring plan

August 2025

Petrofac issues a business update to execute the restructuring and confirms it will appeal the Court of Appeal decision

October 2025

Petrofac loses a major TenneT offshore wind contract worth €13 billion. Holding company files for administration in the UK. Petrofac delisted from the London Stock Exchange

November 2025

180 Petrofac employees laid off in the UAE

JAPANESE GRAND PRIX INFO

Schedule (All times UAE)
First practice: Friday, 5-6.30am
Second practice: Friday, 9-10.30am
Third practice: Saturday, 7-8am
Qualifying: Saturday, 10-11am
Race: Sunday, 9am-midday 

Race venue: Suzuka International Racing Course
Circuit Length: 5.807km
Number of Laps: 53
Watch live: beIN Sports HD

ORDER OF PLAY ON SHOW COURTS

Centre Court - 4pm (UAE)
Gael Monfils (15) v Kyle Edmund
Karolina Pliskova (3) v Magdalena Rybarikova
Dusan Lajovic v Roger Federer (3)

Court 1 - 4pm
Adam Pavlasek v Novak Djokovic (2)
Dominic Thiem (8) v Gilles Simon
Angelique Kerber (1) v Kirsten Flipkens

Court 2 - 2.30pm
Grigor Dimitrov (13) v Marcos Baghdatis
Agnieszka Radwanska (9) v Christina McHale
Milos Raonic (6) v Mikhail Youzhny
Tsvetana Pironkova v Caroline Wozniacki (5)

COMPANY PROFILE
Name: Kumulus Water
 
Started: 2021
 
Founders: Iheb Triki and Mohamed Ali Abid
 
Based: Tunisia 
 
Sector: Water technology 
 
Number of staff: 22 
 
Investment raised: $4 million 
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TRAP

Starring: Josh Hartnett, Saleka Shyamalan, Ariel Donaghue

Director: M Night Shyamalan

Rating: 3/5

Company info

Company name: Entrupy 

Co-founders: Vidyuth Srinivasan, co-founder/chief executive, Ashlesh Sharma, co-founder/chief technology officer, Lakshmi Subramanian, co-founder/chief scientist

Based: New York, New York

Sector/About: Entrupy is a hardware-enabled SaaS company whose mission is to protect businesses, borders and consumers from transactions involving counterfeit goods.  

Initial investment/Investors: Entrupy secured a $2.6m Series A funding round in 2017. The round was led by Tokyo-based Digital Garage and Daiwa Securities Group's jointly established venture arm, DG Lab Fund I Investment Limited Partnership, along with Zach Coelius. 

Total customers: Entrupy’s customers include hundreds of secondary resellers, marketplaces and other retail organisations around the world. They are also testing with shipping companies as well as customs agencies to stop fake items from reaching the market in the first place. 

Directed by: Craig Gillespie

Starring: Emma Stone, Emma Thompson, Joel Fry

4/5

Tips to keep your car cool
  • Place a sun reflector in your windshield when not driving
  • Park in shaded or covered areas
  • Add tint to windows
  • Wrap your car to change the exterior colour
  • Pick light interiors - choose colours such as beige and cream for seats and dashboard furniture
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Brief scoreline:

Manchester United 2

Rashford 28', Martial 72'

Watford 1

Doucoure 90'

Updated: July 13, 2021, 3:36 PM