Wolves v Manchester United (7.30pm): After the highs of thrashing Leeds 5-1, United were held to a frustrating draw at Southampton last time out. Mason Greenwood is aiming to score for the third game in a row, while Jadon Sancho will be champing at the bit for his first start. Wolves are still without a goal or a point - and will get no joy here. Prediction: Wolves 0 Manchester United 2. Reuters
SATURDAY - Manchester City v Arsenal (3.30pm kick-off UAE): Gabriel Jesus, fresh from his three assists in the 5-0 win over Norwich last week, will be looking to increase the pressure on former City coach Mikel Arteta, now in charge at Arsenal. No respite for the struggling Gunners here. Prediction: City 3 Arsenal 1. Reuters
Aston Villa v Brentford (6pm): Summer signing Danny Ings' spectacular bicycle kick put Villa on the road to victory against Newcastle on Saturday, making it two goals in two games since joining from Southampton. Brentford's four points from two games is a fine start to the new campaign but their first defeat is in the post. If only just. Prediction: Villa 2 Brentford 1. Getty
Brighton v Everton (6pm): The Seagulls are the unlikely upstarts knocking on the door of top spot after two wins on the spin but will find Everton a tougher proposition than Burnley or Watford. Rafa Benitez has enjoyed a solid start to his Everton reign with four points from a possible six and three more on their way here. Prediction: Brighton 1 Everton 2. Reuters
Newcastle v Southampton (6pm): Alarm bells ringing already on Tyneside following Saturday's dismal loss at Aston Villa that came hot on the heels of a 4-2 home defeat by West Ham. Back at St James' Park here and facing a Southampton side who were full value for their draw with Manchester United last week. Prediction Newcastle 3 Southampton 2. AFP
Norwich v Leicester (6pm): It has not been the most enjoyable starts to the season for Norwich goalkeeper Tim Krul. Eight goals conceded, including an own goal against Manchester City, and the prospect of a long, hard campaign ahead. Leicester have their own problems with a defensive injury crisis hampering their plans. Prediction: Norwich 1 Leicester 1. Reuters
West Ham v Crystal Palace (6pm): The Hammers are flying high - top of the table and a new record Premier League goalscorer in Michail Antonio. The striker moved onto 49 goals with his double in the 4-1 over Leicester and will fancy reaching his half century against Palace. Prediction: West Ham 3 Palace 1. Getty
Liverpool v Chelsea (8.30pm): A belting heavyweight battle at Anfield that sees two potential title-winners go head-to-head. And all eyes will be on the big guns up front as Liverpool's Mohamed Salah faces off with Chelsea striker Romelu Lukaku. Prediction: Liverpool 1 Chelsea 1. AP
SUNDAY - Burnley v Leeds (5pm): Lancashire takes on Yorkshire at Turf Moor with both teams looking for their first win of the season. Burnley are still without a point, never mind a win, and the wait could well now go on until after the international break with Marcelo Bielsa's side favourites here. Prediction: Burnley 0 Leeds 3. Getty
Tottenham v Watford (5pm): Two welcome sights for Spurs fans in their win at Wolves last week - Dele Alli scoring the only goal and Harry Kane's arrival from the substitutes' bench. Watford came crashing back down to earth after their opening win against Aston Villa when losing 2-0 at Brighton. More of the same for the Hornets here. Prediction: Spurs 2 Watford 0. Getty
Wolves v Manchester United (7.30pm): After the highs of thrashing Leeds 5-1, United were held to a frustrating draw at Southampton last time out. Mason Greenwood is aiming to score for the third game in a row, while Jadon Sancho will be champing at the bit for his first start. Wolves are still without a goal or a point - and will get no joy here. Prediction: Wolves 0 Manchester United 2. Reuters
SATURDAY - Manchester City v Arsenal (3.30pm kick-off UAE): Gabriel Jesus, fresh from his three assists in the 5-0 win over Norwich last week, will be looking to increase the pressure on former City coach Mikel Arteta, now in charge at Arsenal. No respite for the struggling Gunners here. Prediction: City 3 Arsenal 1. Reuters
Aston Villa v Brentford (6pm): Summer signing Danny Ings' spectacular bicycle kick put Villa on the road to victory against Newcastle on Saturday, making it two goals in two games since joining from Southampton. Brentford's four points from two games is a fine start to the new campaign but their first defeat is in the post. If only just. Prediction: Villa 2 Brentford 1. Getty
Brighton v Everton (6pm): The Seagulls are the unlikely upstarts knocking on the door of top spot after two wins on the spin but will find Everton a tougher proposition than Burnley or Watford. Rafa Benitez has enjoyed a solid start to his Everton reign with four points from a possible six and three more on their way here. Prediction: Brighton 1 Everton 2. Reuters
Newcastle v Southampton (6pm): Alarm bells ringing already on Tyneside following Saturday's dismal loss at Aston Villa that came hot on the heels of a 4-2 home defeat by West Ham. Back at St James' Park here and facing a Southampton side who were full value for their draw with Manchester United last week. Prediction Newcastle 3 Southampton 2. AFP
Norwich v Leicester (6pm): It has not been the most enjoyable starts to the season for Norwich goalkeeper Tim Krul. Eight goals conceded, including an own goal against Manchester City, and the prospect of a long, hard campaign ahead. Leicester have their own problems with a defensive injury crisis hampering their plans. Prediction: Norwich 1 Leicester 1. Reuters
West Ham v Crystal Palace (6pm): The Hammers are flying high - top of the table and a new record Premier League goalscorer in Michail Antonio. The striker moved onto 49 goals with his double in the 4-1 over Leicester and will fancy reaching his half century against Palace. Prediction: West Ham 3 Palace 1. Getty
Liverpool v Chelsea (8.30pm): A belting heavyweight battle at Anfield that sees two potential title-winners go head-to-head. And all eyes will be on the big guns up front as Liverpool's Mohamed Salah faces off with Chelsea striker Romelu Lukaku. Prediction: Liverpool 1 Chelsea 1. AP
SUNDAY - Burnley v Leeds (5pm): Lancashire takes on Yorkshire at Turf Moor with both teams looking for their first win of the season. Burnley are still without a point, never mind a win, and the wait could well now go on until after the international break with Marcelo Bielsa's side favourites here. Prediction: Burnley 0 Leeds 3. Getty
Tottenham v Watford (5pm): Two welcome sights for Spurs fans in their win at Wolves last week - Dele Alli scoring the only goal and Harry Kane's arrival from the substitutes' bench. Watford came crashing back down to earth after their opening win against Aston Villa when losing 2-0 at Brighton. More of the same for the Hornets here. Prediction: Spurs 2 Watford 0. Getty
Wolves v Manchester United (7.30pm): After the highs of thrashing Leeds 5-1, United were held to a frustrating draw at Southampton last time out. Mason Greenwood is aiming to score for the third game in a row, while Jadon Sancho will be champing at the bit for his first start. Wolves are still without a goal or a point - and will get no joy here. Prediction: Wolves 0 Manchester United 2. Reuters