Portugal and Cristiano Ronaldo's hopes of World Cup success are over after two goals from Edinson Cavani sank them as they lost 2-1 in Sochi.
The Paris Saint-Germain forward scored once in each half as the Uruguayans prevailed in the second round clash to set up a quarter-final date with France on Friday at the Nizhny Novgorod Stadium.
Cavani had leapt superbly to get on the end of Luis Suarez's cross in the seventh minute to give Uruguay the lead.
Portugal struggled for a response but did level 10 minutes into the second half as Pepe headed home.
But Cavani curled home from the edge of the area in the 62nd minute for what proved to the decisive goal of the game.
It is not all good news for Cavani, however, as he limped off injured before the end and he will be a doubt for the France game.
But for Portugal and Ronaldo the tournament is over and they will depart Russia at some point on Sunday to return home.
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Read more:
World Cup 2018: Day 17 updates - Messi and Argentina beaten by France in thriller
Extra Time podcast: Messi finally comes through as World Cup knockout stages take shape
World Cup 2018 second round guide and predictions: Spain and Croatia to prevail on Sunday
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WWE TLC results
Asuka won the SmackDown Women's title in a TLC triple threat with Becky Lynch and Charlotte Flair
Dean Ambrose won the Intercontinental title against Seth Rollins
Daniel Bryan retained the WWE World Heavyweight Championship against AJ Styles
Ronda Rousey retained the Raw Women's Championship against Nia Jax
Rey Mysterio beat Randy Orton in a chairs match
Finn Balor defeated Drew McIntyre
Natalya beat Ruby Riott in a tables match
Braun Strowman beat Baron Corbin in a TLC match
Sheamus and Cesaro retained the SmackDown Tag Titles against The Usos and New Day
R-Truth and Carmella won the Mixed Match Challenge by beating Jinder Mahal and Alicia Fox
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