Jose Mourinho, the Real Madrid coach, conceded it would be "practically impossible" for his side to win the Primera Division title if Barcelona beat Villarreal later this evening following their shock defeat to Sporting Gijon.
A late strike from Miguel De las Cuevas saw Sporting claim a 1-0 win at the Bernabeu and bring to an end Mourinho's remarkable record of not having lost a home league game as a coach in over nine years.
The loss also ended Madrid's perfect record at the Bernabeu this season, and means Barca will stretch their lead to eight points if they can defeat Villarreal at El Madrigal.
If that happens, Mourinho, while refusing to give up the fight, admits his side's title hopes would be all but sunk with only eight games remaining after this weekend.
When asked if the league had been lost today, Mourinho said: "Until the mathematics say otherwise then no, but looking at things pragmatically and objectively, if today Barca increase their lead to eight points you could say it's practically impossible."
His defender Sergio Ramos added: "A large part of the league has gone away from us. There are very few points left.
"We can't reproach the team for anything. Unfortunately the ball did not go in today. It's very sad to lose with so many chances."
The Spanish giants welcomed back Gonzalo Higuain after over four months out due to a back injury that required surgery and the Argentina international was introduced a second-half substitute.
However, Mourinho was still missing a number of key players for the match with Cristiano Ronaldo, Karim Benzema, Xabi Alonso, Kaka and Marcelo absent through a mixture of injury and suspension.
Without those players Madrid struggled to create anything of note during the first half and, although they laid siege to the Sporting goal in the final 10 minutes, they could find no way through.
Madrid must now lift themselves ahead of Tuesday's Champions League quarter-final first leg against Tottenham, with question marks still surrounding whether Ronaldo will be fit to play.
At yesterday's pre-match press conference Mourinho suggested none of Ronaldo, Benzema or Marcelo would be available until next weekend's league game against Athletic Bilbao.
However, when asked following tonight's game what chance Ronaldo had of making the squad for the Spurs game, Mourinho said: "If he has a chance it's because he and his coach are taking a risk.
"Because the information from the medical department is that he can't play, that he can only play in the game in Bilbao.
"But if the two of us and only the two of us decide that he's going to play then the risk is mine and his.
"Tomorrow I will talk with the injured players and decide if we will risk them."
The defeat saw the end of Mourinho's 150-match unbeaten home league run as coach of Porto, Chelsea, Inter Milan and now Madrid.
The Portuguese said: "Our opponents defended, defended and defended. They had one chance and they scored one goal. I praised them because they fought a lot and they fought to try to have luck on their side.
"We had four, five, six chances to score and we couldn't. That's football and tomorrow's another day."
He added: "We played without the team's most creative players. We lacked creativity. We had to try a different style, more direct with long balls in the air, and we had more opportunities.
"If I had wanted to draw the game 0-0 from the start I would have done so. But a draw was a bad result. Against Tottenham on Tuesday, it won't be. If we draw at home, it would not be a drama because we will have the return to play in London."
MATCH INFO
Arsenal 1 (Aubameyang 12’) Liverpool 1 (Minamino 73’)
Arsenal win 5-4 on penalties
Man of the Match: Ainsley Maitland-Niles (Arsenal)
ARM%20IPO%20DETAILS
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Our legal columnist
Name: Yousef Al Bahar
Advocate at Al Bahar & Associate Advocates and Legal Consultants, established in 1994
Education: Mr Al Bahar was born in 1979 and graduated in 2008 from the Judicial Institute. He took after his father, who was one of the first Emirati lawyers
Nayanthara: Beyond The Fairy Tale
Starring: Nayanthara, Vignesh Shivan, Radhika Sarathkumar, Nagarjuna Akkineni
Director: Amith Krishnan
Rating: 3.5/5
Wicked
Director: Jon M Chu
Stars: Cynthia Erivo, Ariana Grande, Jonathan Bailey
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The specs
Engine: 1.5-litre turbo
Power: 181hp
Torque: 230Nm
Transmission: 6-speed automatic
Starting price: Dh79,000
On sale: Now
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India Test squad
Virat Kohli (c), Mayank Agarwal, Rohit Sharma, Cheteshwar Pujara, Ajinkya Rahane, Hanuma Vihari, Rishabh Pant (wk), Wriddhiman Saha (wk), Ravichandran Ashwin, Ravindra Jadeja, Kuldeep Yadav, Mohammed Shami, Umesh Yadav, Ishant Sharma, Shubman Gill
Men from Barca's class of 99
Crystal Palace - Frank de Boer
Everton - Ronald Koeman
Manchester City - Pep Guardiola
Manchester United - Jose Mourinho
Southampton - Mauricio Pellegrino
Results
1.30pm Handicap (PA) Dh50,000 (Dirt) 1,400m
Winner Al Suhooj, Saif Al Balushi (jockey), Khalifa Al Neyadi (trainer)
2pm Handicap (TB) 68,000 (D) 1,950m
Winner Miracle Maker, Xavier Ziani, Salem bin Ghadayer
2.30pm Maiden (TB) Dh60,000 (D) 1,600m
Winner Mazagran, Tadhg O’Shea, Satish Seemar
3pm Handicap (TB) Dh84,000 (D) 1,800m
Winner Tailor’s Row, Royston Ffrench, Salem bin Ghadayer
3.30pm Handicap (TB) Dh76,000 (D) 1,400m
Winner Alla Mahlak, Adrie de Vries, Rashed Bouresly
4pm Maiden (TB) Dh60,000 (D) 1,200m
Winner Hurry Up, Royston Ffrench, Salem bin Ghadayer
4.30pm Handicap (TB) Dh68,000 (D) 1,200m
TV: World Cup Qualifier 2018 matches will be aired on on OSN Sports HD Cricket channel
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The%20specs
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Indoor cricket in a nutshell
Indoor Cricket World Cup - Sep 16-20, Insportz, Dubai
16 Indoor cricket matches are 16 overs per side
8 There are eight players per team
9 There have been nine Indoor Cricket World Cups for men. Australia have won every one.
5 Five runs are deducted from the score when a wickets falls
4 Batsmen bat in pairs, facing four overs per partnership
Scoring In indoor cricket, runs are scored by way of both physical and bonus runs. Physical runs are scored by both batsmen completing a run from one crease to the other. Bonus runs are scored when the ball hits a net in different zones, but only when at least one physical run is score.
Zones
A Front net, behind the striker and wicketkeeper: 0 runs
B Side nets, between the striker and halfway down the pitch: 1 run
C Side nets between halfway and the bowlers end: 2 runs
D Back net: 4 runs on the bounce, 6 runs on the full
West Asia rugby, season 2017/18 - Roll of Honour
Western Clubs Champions League - Winners: Abu Dhabi Harlequins; Runners up: Bahrain
Dubai Rugby Sevens - Winners: Dubai Exiles; Runners up: Jebel Ali Dragons
West Asia Premiership - Winners: Jebel Ali Dragons; Runners up: Abu Dhabi Harlequins
UAE Premiership Cup - Winners: Abu Dhabi Harlequins; Runners up: Dubai Exiles
UAE Premiership - Winners: Dubai Exiles; Runners up: Abu Dhabi Harlequins
The biog
First Job: Abu Dhabi Department of Petroleum in 1974
Current role: Chairperson of Al Maskari Holding since 2008
Career high: Regularly cited on Forbes list of 100 most powerful Arab Businesswomen
Achievement: Helped establish Al Maskari Medical Centre in 1969 in Abu Dhabi’s Western Region
Future plan: Will now concentrate on her charitable work