A study has shown that the AstraZeneca Covid-19 vaccine is less effective in fighting the the South African variant. AFP.
A study has shown that the AstraZeneca Covid-19 vaccine is less effective in fighting the the South African variant. AFP.
A study has shown that the AstraZeneca Covid-19 vaccine is less effective in fighting the the South African variant. AFP.
A study has shown that the AstraZeneca Covid-19 vaccine is less effective in fighting the the South African variant. AFP.

AstraZeneca Covid shot 'less effective against South African variant'


Neil Murphy
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British drugmaker AstraZeneca said on Saturday its vaccine developed with the University of Oxford appeared to offer only limited protection against mild disease caused by the South African variant of Covid-19, based on early data from a trial.

The study from South Africa's University of the Witwatersrand and Oxford University showed the vaccine had significantly reduced efficacy against the South African variant, according to a Financial Times report.

Among coronavirus variants currently most concerning for scientists and public health experts are the so-called British, South African and Brazilian variants, which appear to spread more swiftly than others.

  • People are seen around Perth, Australia. Western Australia's Covid-19 lockdown restrictions were lifted at 6pm on Friday after no new community coronavirus cases were recorded in the last week. Getty Images
    People are seen around Perth, Australia. Western Australia's Covid-19 lockdown restrictions were lifted at 6pm on Friday after no new community coronavirus cases were recorded in the last week. Getty Images
  • Portuguese Prime Minister António Costa addresses journalists at the end of a visit to a hospital where health care workers were being vaccinated against Covid-19, in Lisbon, Portugal. AP
    Portuguese Prime Minister António Costa addresses journalists at the end of a visit to a hospital where health care workers were being vaccinated against Covid-19, in Lisbon, Portugal. AP
  • Theatre creator Silas Rayner continues with construction work on the "Thorington Theatre in the Woods", a 350 seat capacity performance space, designed by festival business owner Rayner, which is made with local coppiced wood in order to be truly sustainable and set in a natural woodland amphitheatre in Lindy O'Hare's farm estate, amid the spread of the coronavirus disease (COVID-19), near Southwold, Britain. Reuters
    Theatre creator Silas Rayner continues with construction work on the "Thorington Theatre in the Woods", a 350 seat capacity performance space, designed by festival business owner Rayner, which is made with local coppiced wood in order to be truly sustainable and set in a natural woodland amphitheatre in Lindy O'Hare's farm estate, amid the spread of the coronavirus disease (COVID-19), near Southwold, Britain. Reuters
  • Members of the World Health Organisation team tasked with investigating the origins of Covid-19 walk down a corridor after meetings with the Chinese side in the cordoned wing of their hotel in Wuhan in central China's Hubei province. AP Photo
    Members of the World Health Organisation team tasked with investigating the origins of Covid-19 walk down a corridor after meetings with the Chinese side in the cordoned wing of their hotel in Wuhan in central China's Hubei province. AP Photo
  • Dominic Dwyer, a member of the World Health Organisation team tasked with investigating the origins of Covid-19, walks at a hotel in Wuhan, Hubei province, China. Reuters
    Dominic Dwyer, a member of the World Health Organisation team tasked with investigating the origins of Covid-19, walks at a hotel in Wuhan, Hubei province, China. Reuters
  • A staff member wearing a face maskis reflected in the goggles of a skier at the National Alpine Skiing Center in Yanqing on the outskirts of Beijing. Beijing Olympic organisers showed off the downhill skiing venue and the world's longest bobsled and luge track Friday, one year ahead of the scheduled opening of the 2022 Olympic Winter Games. AP Photo
    A staff member wearing a face maskis reflected in the goggles of a skier at the National Alpine Skiing Center in Yanqing on the outskirts of Beijing. Beijing Olympic organisers showed off the downhill skiing venue and the world's longest bobsled and luge track Friday, one year ahead of the scheduled opening of the 2022 Olympic Winter Games. AP Photo
  • A worker welds and seals the aluminum lid of the coffin with a Covid-19 victim in Penafiel, Portugal. Getty Images
    A worker welds and seals the aluminum lid of the coffin with a Covid-19 victim in Penafiel, Portugal. Getty Images
  • A Kansas City Chiefs fan wears a themed face mask ahead of the weekend's Super Bowl LV between the Kansas City Chiefs and Tampa Bay Buccaneers in Tampa, Florida, US. Reuters
    A Kansas City Chiefs fan wears a themed face mask ahead of the weekend's Super Bowl LV between the Kansas City Chiefs and Tampa Bay Buccaneers in Tampa, Florida, US. Reuters
  • Healthcare workers treat a Covid-19 patient in a Step Down Unit at Providence Holy Cross Medical Center in Mission Hills, California, US. Bloomberg
    Healthcare workers treat a Covid-19 patient in a Step Down Unit at Providence Holy Cross Medical Center in Mission Hills, California, US. Bloomberg
  • Immigrants participate in a socially-distanced outdoor naturalisation ceremony to become new US citizens, as the coronavirus outbreak continues, in Los Angeles, California. Reuters
    Immigrants participate in a socially-distanced outdoor naturalisation ceremony to become new US citizens, as the coronavirus outbreak continues, in Los Angeles, California. Reuters
  • Healthcare workers administer Pfizer-BioNTech Covid-19 vaccines at a vaccination site inside a church in the Bronx borough of New York, US. Bloomberg
    Healthcare workers administer Pfizer-BioNTech Covid-19 vaccines at a vaccination site inside a church in the Bronx borough of New York, US. Bloomberg
  • Buddhist monks wear face masks as they receive alms from devotees in Phnom Penh, Cambodia. AP Photo
    Buddhist monks wear face masks as they receive alms from devotees in Phnom Penh, Cambodia. AP Photo
  • Workers leave after burying a victim of coronavirus at a Muslim cemetery in Gombak, outskirts of Kuala Lumpur, Malaysia. AP Photo
    Workers leave after burying a victim of coronavirus at a Muslim cemetery in Gombak, outskirts of Kuala Lumpur, Malaysia. AP Photo
  • People wearing face masks rest at Hinokicho Park in Tokyo. AP Photo
    People wearing face masks rest at Hinokicho Park in Tokyo. AP Photo
  • Women wearing face masks as a precaution against the coronavirus ride on a scooter past boats displayed for sale by a roadside in Alappuzha, Kerala state, India. AP Photo
    Women wearing face masks as a precaution against the coronavirus ride on a scooter past boats displayed for sale by a roadside in Alappuzha, Kerala state, India. AP Photo
  • Beneficiaries wait for their turn to get her first dose of a Covid-19 vaccine shot, manufactured by Serum Institute of India, inside Vaccination Centre at Shatabdi Hospital in Mumbai, India. EPA
    Beneficiaries wait for their turn to get her first dose of a Covid-19 vaccine shot, manufactured by Serum Institute of India, inside Vaccination Centre at Shatabdi Hospital in Mumbai, India. EPA

"In this small phase I/II trial, early data has shown limited efficacy against mild disease primarily due to the B. 1.351 South African variant," an AstraZeneca spokesman said.

"However, we have not been able to properly ascertain its effect against severe disease and hospitalisation given that subjects were predominantly young healthy adults."

The company said it believed its vaccine could protect against severe disease, given that the neutralising antibody activity was equivalent to that of other Covid-19 vaccines.

While thousands of individual changes have arisen as the virus mutates into new variants, only a tiny minority are likely to be important or change the virus in an appreciable way, according to the British Medical Journal.

"Oxford University and AstraZeneca have started adapting the vaccine against this variant and will advance rapidly through clinical development so that it is ready for Autumn delivery should it be needed," the AstraZeneca spokesman said.

The trial involving more than 2,000 people has not been peer-reviewed, the FT said.

On Friday Oxford said their vaccine has similar efficacy against the British coronavirus variant as it does to the previously circulating variants.

Ziina users can donate to relief efforts in Beirut

Ziina users will be able to use the app to help relief efforts in Beirut, which has been left reeling after an August blast caused an estimated $15 billion in damage and left thousands homeless. Ziina has partnered with the United Nations High Commissioner for Refugees to raise money for the Lebanese capital, co-founder Faisal Toukan says. “As of October 1, the UNHCR has the first certified badge on Ziina and is automatically part of user's top friends' list during this campaign. Users can now donate any amount to the Beirut relief with two clicks. The money raised will go towards rebuilding houses for the families that were impacted by the explosion.”

Ferrari 12Cilindri specs

Engine: naturally aspirated 6.5-liter V12

Power: 819hp

Torque: 678Nm at 7,250rpm

Price: From Dh1,700,000

Available: Now

Meydan racecard:

6.30pm: Al Maktoum Challenge Round 2 (PA) Group 1 | US$75,000 (Dirt) | 2,200 metres

7.05pm: UAE 1000 Guineas (TB) Listed | $250,000 (D) 1,600m

7.40pm: Meydan Classic Trial (TB) Conditions $100,000 (Turf) 1,400m

8.15pm: Al Shindagha Sprint (TB) Group 3 $200,000 (D) 1,200m

8.50pm: Handicap (TB) $175,000 (D) 1,600m

9.25pm: Handicap (TB) $175,000 (T) | 2,000m

10pm: Handicap (TB) $135,000 (T) 1,600m

Slow loris biog

From: Lonely Loris is a Sunda slow loris, one of nine species of the animal native to Indonesia, Malaysia, Thailand and Singapore

Status: Critically endangered, and listed as vulnerable on the International Union for Conservation of Nature red list due to growing demand in the global exotic pet trade. It is one of the most popular primate species found at Indonesian pet markets

Likes: Sleeping, which they do for up to 18 hours a day. When they are awake, they like to eat fruit, insects, small birds and reptiles and some types of vegetation

Dislikes: Sunlight. Being a nocturnal animal, the slow loris wakes around sunset and is active throughout the night

Superpowers: His dangerous elbows. The slow loris’s doe eyes may make it look cute, but it is also deadly. The only known venomous primate, it hisses and clasps its paws and can produce a venom from its elbow that can cause anaphylactic shock and even death in humans

How will Gen Alpha invest?

Mark Chahwan, co-founder and chief executive of robo-advisory firm Sarwa, forecasts that Generation Alpha (born between 2010 and 2024) will start investing in their teenage years and therefore benefit from compound interest.

“Technology and education should be the main drivers to make this happen, whether it’s investing in a few clicks or their schools/parents stepping up their personal finance education skills,” he adds.

Mr Chahwan says younger generations have a higher capacity to take on risk, but for some their appetite can be more cautious because they are investing for the first time. “Schools still do not teach personal finance and stock market investing, so a lot of the learning journey can feel daunting and intimidating,” he says.

He advises millennials to not always start with an aggressive portfolio even if they can afford to take risks. “We always advise to work your way up to your risk capacity, that way you experience volatility and get used to it. Given the higher risk capacity for the younger generations, stocks are a favourite,” says Mr Chahwan.

Highlighting the role technology has played in encouraging millennials and Gen Z to invest, he says: “They were often excluded, but with lower account minimums ... a customer with $1,000 [Dh3,672] in their account has their money working for them just as hard as the portfolio of a high get-worth individual.”

THE DETAILS

Kaala

Dir: Pa. Ranjith

Starring: Rajinikanth, Huma Qureshi, Easwari Rao, Nana Patekar  

Rating: 1.5/5 

Ten tax points to be aware of in 2026

1. Domestic VAT refund amendments: request your refund within five years

If a business does not apply for the refund on time, they lose their credit.

2. E-invoicing in the UAE

Businesses should continue preparing for the implementation of e-invoicing in the UAE, with 2026 a preparation and transition period ahead of phased mandatory adoption. 

3. More tax audits

Tax authorities are increasingly using data already available across multiple filings to identify audit risks. 

4. More beneficial VAT and excise tax penalty regime

Tax disputes are expected to become more frequent and more structured, with clearer administrative objection and appeal processes. The UAE has adopted a new penalty regime for VAT and excise disputes, which now mirrors the penalty regime for corporate tax.

5. Greater emphasis on statutory audit

There is a greater need for the accuracy of financial statements. The International Financial Reporting Standards standards need to be strictly adhered to and, as a result, the quality of the audits will need to increase.

6. Further transfer pricing enforcement

Transfer pricing enforcement, which refers to the practice of establishing prices for internal transactions between related entities, is expected to broaden in scope. The UAE will shortly open the possibility to negotiate advance pricing agreements, or essentially rulings for transfer pricing purposes. 

7. Limited time periods for audits

Recent amendments also introduce a default five-year limitation period for tax audits and assessments, subject to specific statutory exceptions. While the standard audit and assessment period is five years, this may be extended to up to 15 years in cases involving fraud or tax evasion. 

8. Pillar 2 implementation 

Many multinational groups will begin to feel the practical effect of the Domestic Minimum Top-Up Tax (DMTT), the UAE's implementation of the OECD’s global minimum tax under Pillar 2. While the rules apply for financial years starting on or after January 1, 2025, it is 2026 that marks the transition to an operational phase.

9. Reduced compliance obligations for imported goods and services

Businesses that apply the reverse-charge mechanism for VAT purposes in the UAE may benefit from reduced compliance obligations. 

10. Substance and CbC reporting focus

Tax authorities are expected to continue strengthening the enforcement of economic substance and Country-by-Country (CbC) reporting frameworks. In the UAE, these regimes are increasingly being used as risk-assessment tools, providing tax authorities with a comprehensive view of multinational groups’ global footprints and enabling them to assess whether profits are aligned with real economic activity. 

Contributed by Thomas Vanhee and Hend Rashwan, Aurifer