The Chinese scientist who ignited a backlash over claims he edited the genes of two newborn girls is a youthful outsider who believes history will be on his side when the dust settles.
He Jiankui, a researcher in the southern Chinese city of Shenzhen, said Monday that he altered the genes of a pair of twin girls while they were embryos to try to make the babies resistant to infection by the virus that causes AIDS.
He, a virtual unknown in the world of gene-editing who crossed the boundaries of the scientific community’s self-imposed ethical lines, will make the project’s data public Wednesday at an international genetics conference in Hong Kong, according to a representative. Before even publishing proof of the results, he faces condemnation from his university, other scientists, and even a government official, who said that any gene editing for fertility purposes was unlawful.“I understand my work will be controversial, but I believe families need this technology, and I’m willing to take the criticism for them,” He said in a video posted Nov. 25 on YouTube.
The scientist, a soccer fan in his mid-thirties who did not respond to requests for comment, used a technology called Crispr, a tool now widely used for the modification of genes in research. He worked almost alone. His research team appears to consist of one other fully-qualified scientist, the embryologist Qin Jinzhou, who conducted the actual gene surgery and in-vitro fertilization, according to the YouTube video.
“We believe ethics are on our side of history,” He said in another video described by ScienceNet.cn, a publication of China Science Daily which is backed by the Chinese Academy of Sciences.
He is based in China, at the Southern University of Science and Technology, or SUSTC, in Shenzhen, but did his graduate and post-graduate training in the U.S. He got a PhD at Rice University in Houston, then did further research work at Stanford University in California from 2011 to 2012 before returning to China, according to his biographical page on SUSTC’s website.
There’s little clue in his background that He would become controversial for a first-in-the-world human experimentation. Mr He’s earlier work in the U.S. was largely theoretical and focused on biophysics and computational genomics, according to published papers and a U.S. researcher who worked with him in the past. Computational genomics involves using powerful computing tools to study large amounts of DNA data, often far removed from clinical medicine.
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One of his first academic papers on Crispr was published in 2010 by a physics journal and focused on a theoretical model of how bacteria use gene-editing to defend themselves. During post-doctoral work at Stanford, his research was far removed from human experimentation and focused on computational genomics, according to the researcher, who described He as bright, ambitious, outgoing and entrepreneurial.
The Southern University of Science and Technology said in a statement on its website that it was “shocked” at the news of Mr He’s actions and that the researcher has been on unpaid leave since February. It didn’t provide details about the reason for the leave.
Harmonicare Medical Holdings Ltd., the Hong Kong-listed operator of the Shenzhen hospital He said he received approval from, said it did not participate in any clinical trial related to gene-edited babies and that the babies were not delivered there. A group of 122 Chinese scientists issued a joint statement decrying Mr He’s actions as “madness” and called for the government to regulate the work.
A Chinese official on Tuesday emphasized at a press briefing that China had outlawed the use of gene-editing for fertility purposes in 2003. It’s unclear what penalties researchers who run afoul of the rules may face. China’s National Health Commission also asked regional authorities to investigate his claim.
He rose to prominence in China by designing fast and cheap gene-sequencing machines through his start-up Direct Genomics, based in Shenzhen. Sina.com, an established Chinese news publication, reported in April that Direct Genomics received 218 million yuan (Dh 115 million) in venture capital funding that month.
Last year, He was awarded a place in China’s prestigious Thousand Talents program -- the government’s scheme to lure back top researchers from overseas with grants and research resources. Interviews and profiles published in recent years in local media reveal a driven, idealistic scientist who switched to biology only in his fourth year of university.
In the videos on YouTube, He outlines what he thinks should be the ethics of the technology, including its use “only for serious disease, never vanity” and “genes do not define you.”
Gene editing “is only meant to help a small number of families. For a few children, early gene surgery may be the only available way to heal an inheritable disease and prevent a lifetime of suffering. We hope you have mercy for them,” He said in one of the YouTube videos.
The videos show an earnest, clean-cut man explaining to the camera how he wanted to help families stricken with the stigma of HIV. He condemned non-medical use of gene-editing tools, saying such uses should be outlawed as they are in the U.S. and other countries.
“Their parents don’t want a designer baby, just child who won’t suffer from a disease which medicine now prevent,” He said. “Gene surgery is and should remain a technology for healing. Enhancing IQ of hair or eye colour isn’t what a loving parent does. That should be banned.”
How to help
Send “thenational” to the following numbers or call the hotline on: 0502955999
2289 – Dh10
2252 – Dh 50
6025 – Dh20
6027 – Dh 100
6026 – Dh 200
Draw:
Group A: Egypt, DR Congo, Uganda, Zimbabwe
Group B: Nigeria, Guinea, Madagascar, Burundi
Group C: Senegal, Algeria, Kenya, Tanzania
Group D: Morocco, Ivory Coast, South Africa, Namibia
Group E: Tunisia, Mali, Mauritania, Angola
Group F: Cameroon, Ghana, Benin, Guinea-Bissau
Day 2, Abu Dhabi Test: At a glance
Moment of the day Dinesh Chandimal has inherited a challenging job, after being made Sri Lanka’s Test captain. He responded in perfect fashion, with an easy-natured century against Pakistan. He brought up three figures with a majestic cover drive, which he just stood and admired.
Stat of the day – 33 It took 33 balls for Dilruwan Perera to get off the mark. His time on zero was eventful enough. The Sri Lankan No 7 was given out LBW twice, but managed to have both decisions overturned on review. The TV replays showed both times that he had inside edged the ball onto his pad.
The verdict In the two previous times these two sides have met in Abu Dhabi, the Tests have been drawn. The docile nature of proceedings so far makes that the likely outcome again this time, but both sides will be harbouring thoughts that they can force their way into a winning position.
Adele: The Stories Behind The Songs
Caroline Sullivan
Carlton Books
THE BIG MATCH
Arsenal v Manchester City,
Sunday, Emirates Stadium, 6.30pm
More on animal trafficking
Europe’s rearming plan
- Suspend strict budget rules to allow member countries to step up defence spending
- Create new "instrument" providing €150 billion of loans to member countries for defence investment
- Use the existing EU budget to direct more funds towards defence-related investment
- Engage the bloc's European Investment Bank to drop limits on lending to defence firms
- Create a savings and investments union to help companies access capital
The biog
Born: Kuwait in 1986
Family: She is the youngest of seven siblings
Time in the UAE: 10 years
Hobbies: audiobooks and fitness: she works out every day, enjoying kickboxing and basketball
The distance learning plan
Spring break will be from March 8 - 19
Public school pupils will undergo distance learning from March 22 - April 2. School hours will be 8.30am to 1.30pm
Staff will be trained in distance learning programmes from March 15 - 19
Teaching hours will be 8am to 2pm during distance learning
Pupils will return to school for normal lessons from April 5
Fight card
1. Featherweight 66kg: Ben Lucas (AUS) v Ibrahim Kendil (EGY)
2. Lightweight 70kg: Mohammed Kareem Aljnan (SYR) v Alphonse Besala (CMR)
3. Welterweight 77kg:Marcos Costa (BRA) v Abdelhakim Wahid (MAR)
4. Lightweight 70kg: Omar Ramadan (EGY) v Abdimitalipov Atabek (KGZ)
5. Featherweight 66kg: Ahmed Al Darmaki (UAE) v Kagimu Kigga (UGA)
6. Catchweight 85kg: Ibrahim El Sawi (EGY) v Iuri Fraga (BRA)
7. Featherweight 66kg: Yousef Al Husani (UAE) v Mohamed Allam (EGY)
8. Catchweight 73kg: Mostafa Radi (PAL) v Ahmed Abdelraouf of Egypt (EGY)
9. Featherweight 66kg: Jaures Dea (CMR) v Andre Pinheiro (BRA)
10. Catchweight 90kg: Tarek Suleiman (SYR) v Juscelino Ferreira (BRA)
Points tally
1. Australia 52; 2. New Zealand 44; 3. South Africa 36; 4. Sri Lanka 35; 5. UAE 27; 6. India 27; 7. England 26; 8. Singapore 8; 9. Malaysia 3
The specs
Engine: 3.0-litre six-cylinder turbo
Power: 398hp from 5,250rpm
Torque: 580Nm at 1,900-4,800rpm
Transmission: Eight-speed auto
Fuel economy, combined: 6.5L/100km
On sale: December
Price: From Dh330,000 (estimate)
Killing of Qassem Suleimani
MATCH INFO
Bangla Tigers 108-5 (10 ovs)
Ingram 37, Rossouw 26, Pretorius 2-10
Deccan Gladiators 109-4 (9.5 ovs)
Watson 41, Devcich 27, Wiese 2-15
Gladiators win by six wickets
The specs: 2018 Honda City
Price, base: From Dh57,000
Engine: 1.5L, in-line four-cylinder
Transmission: Continuously variable transmission
Power: 118hp @ 6,600rpm
Torque: 146Nm @ 4,600rpm
Fuel economy, combined: 5.8L / 100km
RESULTS
6.30pm Handicap (TB) $68,000 (Dirt) 1,200m
Winner Canvassed, Par Dobbs (jockey), Doug Watson (trainer)
7.05pm Meydan Cup – Listed Handicap (TB) $88,000 (Turf) 2,810m
Winner Dubai Future, Frankie Dettori, Saeed bin Suroor
7.40pm UAE 2000 Guineas – Group 3 (TB) $125,000 (D) 1,600m
Winner Mouheeb, Ryan Curatolo, Nicholas Bachalard
8.15pm Firebreak Stakes – Group 3 (TB) $130,000 (D) 1,600m
Winner Secret Ambition, Tadhg O’Shea, Satish Seemar
9.50pm Meydan Classic – Conditions (TB) $$50,000 (T) 1,400m
Winner Topper Bill, Richard Mullen, Satish Seemar
9.25pm Dubai Sprint – Listed Handicap (TB) $88,000 (T) 1,200m
Winner Man Of Promise, William Buick, Charlie Appleby
The specs
AT4 Ultimate, as tested
Engine: 6.2-litre V8
Power: 420hp
Torque: 623Nm
Transmission: 10-speed automatic
Price: From Dh330,800 (Elevation: Dh236,400; AT4: Dh286,800; Denali: Dh345,800)
On sale: Now
COMPANY%20PROFILE
%3Cp%3E%3Cstrong%3ECompany%20name%3A%3C%2Fstrong%3E%20Revibe%20%0D%3Cbr%3E%3Cstrong%3EStarted%3A%3C%2Fstrong%3E%202022%0D%3Cbr%3E%3Cstrong%3EFounders%3A%3C%2Fstrong%3E%20Hamza%20Iraqui%20and%20Abdessamad%20Ben%20Zakour%20%0D%3Cbr%3E%3Cstrong%3EBased%3A%3C%2Fstrong%3E%20UAE%20%0D%3Cbr%3E%3Cstrong%3EIndustry%3A%3C%2Fstrong%3E%20Refurbished%20electronics%20%0D%3Cbr%3E%3Cstrong%3EFunds%20raised%20so%20far%3A%3C%2Fstrong%3E%20%2410m%20%0D%3Cbr%3E%3Cstrong%3EInvestors%3A%20%3C%2Fstrong%3EFlat6Labs%2C%20Resonance%20and%20various%20others%0D%3C%2Fp%3E%0A
PFA Team of the Year: David de Gea, Kyle Walker, Jan Vertonghen, Nicolas Otamendi, Marcos Alonso, David Silva, Kevin De Bruyne, Christian Eriksen, Harry Kane, Mohamed Salah, Sergio Aguero
The details
Heard It in a Past Life
Maggie Rogers
(Capital Records)
3/5
Results
3pm: Handicap (PA) Dh40,000 (Dirt) 1,000m; Winner: Dhafra, Antonio Fresu (jockey), Eric Lemartinel (trainer)
3.30pm: Maiden (PA) Dh40,000 (D) 2,000m; Winner: Al Ajayib, Antonio Fresu, Eric Lemartinel
4pm: Handicap (PA) Dh40,000 (D) 1,700m; Winner: Ashtr, Abdul Aziz Al Balushi, Majed Al Jahouri
4.30pm: Handicap (TB) Dh40,000 (D) 1,700m; Winner: Falcon Claws, Szczepan Mazur, Doug Watson
5pm: Sheikh Dr Sultan bin Khalifa Al Nahyan Cup – Prestige Handicap (PA) Dh100,000 (D) 1,700m; Winner: Al Mufham SB, Al Moatasem Al Balushi, Badar Al Hajri
5.30pm: Sharjah Marathon – Handicap (PA) Dh70,000 (D) 2,700m; Winner: Asraa Min Al Talqa, Al Moatasem Al Balushi, Helal Al Alawi
SPECS
Toyota land Cruiser 2020 5.7L VXR
Engine: 5.7-litre V8
Transmission: eight-speed automatic
Power: 362hp
Torque: 530Nm
Price: Dh329,000 (base model 4.0L EXR Dh215,900)
Day 1 results:
Open Men (bonus points in brackets)
New Zealand 125 (1) beat UAE 111 (3)
India 111 (4) beat Singapore 75 (0)
South Africa 66 (2) beat Sri Lanka 57 (2)
Australia 126 (4) beat Malaysia -16 (0)
Open Women
New Zealand 64 (2) beat South Africa 57 (2)
England 69 (3) beat UAE 63 (1)
Australia 124 (4) beat UAE 23 (0)
New Zealand 74 (2) beat England 55 (2)
Know your camel milk:
Flavour: Similar to goat’s milk, although less pungent. Vaguely sweet with a subtle, salty aftertaste.
Texture: Smooth and creamy, with a slightly thinner consistency than cow’s milk.
Use it: In your morning coffee, to add flavour to homemade ice cream and milk-heavy desserts, smoothies, spiced camel-milk hot chocolate.
Goes well with: chocolate and caramel, saffron, cardamom and cloves. Also works well with honey and dates.
UAE jiu-jitsu squad
Men: Hamad Nawad and Khalid Al Balushi (56kg), Omar Al Fadhli and Saeed Al Mazroui (62kg), Taleb Al Kirbi and Humaid Al Kaabi (69kg), Mohammed Al Qubaisi and Saud Al Hammadi (70kg), Khalfan Belhol and Mohammad Haitham Radhi (85kg), Faisal Al Ketbi and Zayed Al Kaabi (94kg)
Women: Wadima Al Yafei and Mahra Al Hanaei (49kg), Bashayer Al Matrooshi and Hessa Al Shamsi (62kg)
MATCH INFO
Everton 0
Manchester City 2 (Laporte 45 2', Jesus 90 7')
