Oprah Winfrey has, in her five-decade career, conducted more than 37,000 interviews. Among those to join her on the sofa of <em>The Oprah Winfrey Show </em>have been some of the world's biggest names. From presidents to Hollywood greats and everything in between, there have been plenty of shocking and memorable moments. And as it is announced the talk show host will sit down with the <a href="https://www.thenationalnews.com/world/europe/prince-harry-and-meghan-to-break-silence-in-oprah-interview-1.1166812">Duke and Duchess of Sussex</a> in March, for their first interview since stepping back as senior members of the British royal family, the world waits with bated breath to hear what they will have to say. Until then, here are seven of the biggest interviews Oprah has done over the years: In 1993, Winfrey was personally invited to Michael Jackson's Neverland Ranch for an interview with the notoriously private star. The interview went on to become the most watched in television history, thanks in part to the <em>Thriller </em>star's unusual openness, which saw him discuss everything from his relationship with his father to his skin condition, vitiligo. Former wife of Prince Andrew, Sarah Ferguson, the Duchess of York, has been interviewed by Oprah on a number of occasions. However, the most notable was her 1996 appearance on <em>The Oprah Winfrey Show</em> – the year of her divorce – in which she spoke of the breakdown of her marriage, and was critical of the British media, calling them "invasive" and "cruel". She was also interviewed in 2011 after British tabloid <em>News of the World</em> leaked video footage of her accepting a bribe in exchange for access to Prince Andrew the year before. In 2005, <a href="https://www.thenationalnews.com/arts-culture/film/why-tom-cruise-and-mission-impossible-look-set-to-return-to-abu-dhabi-1.1150227">Tom Cruise</a> provided one of the most talked-about moments in the history of <em>The Oprah Winfrey Show </em>when he famously leapt on to the couch to declare his love for then-girlfriend Katie Holmes. The hyperactive, chaotic interview with Cruise – who was arguably one of Hollywood's biggest stars at the time – was one of the first videos to truly go viral on <a href="https://www.thenationalnews.com/arts-culture/here-are-the-first-ever-youtube-videos-top-10-oldest-youtube-videos-1.1009684">newly-launched YouTube</a>, and would provide enough gossip page fodder to keep columnists in business for months. In 2009, Oprah sat down with Whitney Houston for what became one of her most shocking interviews ever. The singer got candid about the breakdown of her 14-year marriage to Bobby Brown, discussing alleged infidelity as well as emotional and physical abuse. She also spoke of her struggles to overcome addiction. Then-US president Barack Obama and the first lady, Michelle Obama sat down with Oprah in 2011, becoming the first sitting president to appear on the show. For the interview, the trio took a trip to the Obamas's hometown of Chicago. President Obama opened up about his love for his wife and children, and Oprah admitted it was one of only a small handful of times she felt nervous to interview one of her guests, describing it as an "out of body" experience. For <em>Oprah's Next Chapter</em> in 2012, Rihanna took Oprah on a tour of her childhood neighbourhood in Barbados, before sitting down for a lengthy chat in which she discussed the violence she experienced at the hands of her former boyfriend, R'n'B star Chris Brown. Speaking of the media circus that followed the incident, an emotional Rihanna said: “It was a weird space to be in, because as angry as I was, as angry and hurt and betrayed, I just felt like, he made that mistake because he needed help, and who’s going to help him. Nobody is going to say he needs help, everybody is going to say he is a monster.” After years of denying allegations, in 2013, Lance Armstrong finally admitted to using performance-enhancing drugs in cycling races. He sat down with Oprah for a tell-all interview, where he addressed the controversy for the first time on camera. 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